Background: Use of contrast media in CT scans has been cited as one of the most common causes of iatrogenic acute kidney injury.  Its use however improves the diagnostic accuracy of CT scans.  Some studies have even reported an incidence of contrast induced nephropathy (CIN) as high as 14%.  Many of the studies coming to these conclusions were performed before the use of low- and iso-osmolar contrast agents.


 Risk of Acute Kidney Injury After Intravenous Contrast Media Administration

  • Single center retrospective cohort analysis of >17,000 patients who underwent contrast enhanced, non-contrast enhanced, or no CT
  • Intervention: CT scan with or without intravenous contrast


Author Conclusion: “In the largest well-controlled study of acute kidney injury following contrast administration in the ED to date, intravenous contrast was not associated with an increased frequency of acute kidney injury.”

Clinical Take Home Point: It is time for a controlled randomized prospective trial to determine if the newer hypo- and iso-osmolar intravenous contrast media lead to the development of acute kidney injury or not.